Study of the electrochemical behavior of Gabapentin at surface of glassy carbon electrode modified by Prussian blue and carbon nanotube

Gabapentin is a useful drug used to treat seizures and neuropathic pa in. It is also can be used for treatment of anxiety disorders insomnia, and bipolar disorder . electrochemical techniques have been proven to be very sensitive to the determination of drugs and related molecules [1].In this work, Prussian b lue (PB)and carbon nanotubes (CN) used as intermediate for electron transfer modified glassy carbon (GC) electrode [2]. Electrochemical properties of the modifi ed electrode showed that electrocatalytic oxidation of Gabapentin were evaluated in comparison with unmodified electrode, the electrode catalytic activity for oxidation of Gabapentin revealed that the (PB-GCM) and(CN-GCM),a large anodic peak appear s, indicating that the anodic oxidation of Gabapentin could be catalyzed at (PB-GCM)and(CN-GCM) electrodes. The anodic peak, 110mV for (PB) and 180mV for (CN) displaced to more negative potentials.The kinetic parameters such as the electron transfer coefficient (α) and the number of electrons involved in the rate-determining step (nα) for the oxidation of Gabapentin were determined utilizing cyclic voltammetry (CV). Also diffusion co efficient was estimated used chronoampro mmetry.

کلیدواژه ها:

Gabapentin ، Prussian blue ، carbon nanotubes