Synthesis of 2-substituted Perimidine Derivatives using Nanosawdust/ TiCl4 as a Green Catalyst under Solvent-free Condition

Perimidines are a kind of heterocycles containing a dihydropyrimidine ring and peri-fused to the naphthalene structure [1]. Multinuclear N-heterocyclic compounds, such asperimidines, are of wide interest because they exhibit a diverse range of biological activities. Among their multiple applications in pharmaceutics, including also activity asantiulcer, antifungal, antimicrobial, immunosuppres- sive agents and enzyme inhibitors, a particular interest is assumed by the established chemotherapeutic, anti-cancer and antiproliferative properties of perimidine derivatives [2]. The most commonly method for the preparation of perimidines is the condensation reaction of 1, 8-diaminonaphthalene with a carbonyl group, which requires a special reagent or force reaction conditions [3]. Many procedures for the synthesis of dihydroperimidines have been reported in the presence of various catalysts. Herein, we wish report the synthesis of dihydroperimidines using various aromatic aldehydes and 1,8- diaminonaphthalene in the presence of nanosawdust/TiCl4 as a green catalyst under solvent-free conditions (Scheme1).The advantages of this work are simple work-up, mild condition, short reaction time and high yields.