An efficient method for the one-pot synthesis of 4-phenyl-hydrazineyl thiazole derivatives using nano-SiO2

Thiazoles are widely found in bioorganic and medicinal chemistry with application in drug discovery. Thiazoles exhibit diverse biological activities such as antimicrobial [1], and anti-diabetic [2] activities. Also, various thiazoles such as 2-arylthiazole received much attention due to unique structure and its usage as anticancer agents [3]. In this research, one-pot three-component synthesis of 4-phenyl-hydrazineyl thiazole derivatives was developed by a condensation of various acetophenones, phenacyl chloride, and thiosemicarbazid in the presence of nano-SiO2 in ethanol at reflux conditions (Scheme 1). The products formed in excellent yields over short reaction times under an environmentally friendly conditions.