Bioinformatics predictionof long-non coding RNAs as expression regulatory candidates of genes involving in myelination
- سال انتشار: 1397
- محل انتشار: بیستمین کنگره ملی و هشتمین کنگره بین‌المللی زیست‌شناسی ایران
- کد COI اختصاصی: BIOCONF20_515
- زبان مقاله: انگلیسی
- تعداد مشاهده: 490
نویسندگان
Department of Genetics, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran
Department of Genetics, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran
Department of Genetics, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran
چکیده
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system, afflicting approximately 2.5 million people worldwide, and imposes a great personal and socioeconomic burden. In the most common form of MS, relapsing-remitting, the demyelinated lesions will undergo remyelination and result in remission, after each rout. But in the passing time, improvement during each remission wanes, and about 80%of patients go on to develop secondary progressive multiple sclerosis, which shows accumulative disabilities. Therefore, understanding dysregulated mechanisms involved in repair of lesions and remyelination would be important in order to help to improve the quality of patient s life. CNTF, NTF3, FGF2, and PDGFC as secreted factors from astrocytes and affecting myelination, were chosen. All of the transcription factors (TFs) affecting these genes were searched. Using the UCSC database, the valid TFs, and using JASPAR database, the predicted ones with a high score were chosen. The TFs common among all of the target genes were chosen. Long non-coding RNAs (lncRNAs) related to these TFs were obtained using Lncrna2Target database and literature review. Exerting some criteria, like the studied role of candidate lncRNAs in inflammation or other neurodegenerative diseases, narrowed down the list of candidate lncRNAs as a possible regulator of transcription of target genes. Obtained data showed that about 5 lncRNAs have the potential to affect the expression regulation of target genes. Differential expression and functional analysis of lncRNAs as the important factors involved in the regulation of gene expression would pave the way in understanding the impaired mechanisms of repair and remyelinationکلیدواژه ها
Multiple sclerosis, Myelination, Long noncoding RNAمقالات مرتبط جدید
- پروتئین های جدید برای اینده
- چالش گرمایش زمین ، علت ها و راه های مقابله با آن
- بررسی زمین شناسی لایه های زیرسطح با استفاده از روش مقاومت ویژه الکتریکی جهت اکتشاف آب زیرزمینی
- روشهای نوین خاکورزی و استراتژیهای بهبود رطوبت در زمین های کشاورزی دیواندره
- انتخاب ژنوتیپهای مطلوب در جمعیتهای در حال تفکیک گوجه فرنگی
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.