Study of MACC1 gene expression in blood samples of patients with colorectal cancer in west and northwest of Iran

Colorectal Cancer (CRC) is the third most common cancer in the world, with a high prevalence in women and men. In the past three decades, its incidence has increased in Iran. This cancer is usually seen in both hereditary and nonhereditary forms. Today, different biomarkers have been introduced for detection this cancer in early stages. The purpose of this study was to evaluate the expression of MACC1 gene as a metastasis metastasis biomarker in people with colorectal cancer in west and northwestern Iran. over expression of MACC1 by increasing the expression of Met, β-catenin and its downstream genes, including c-Myc, cyclin D1, MMP9, phos-GSK3β (Ser9), MACC1, vimentin, and E-Cadherin HCT116 expression suppression causes colorectal cancer. In this research, blood samples were collected from patients with colorectal cancer and healthy patients for control. After extracting serum RNA from the MACC1 gene, its expression was measured using RT-PCR. In the results, the increase in MACC1 gene expression was observed in 67% of patients with colorectal cancer, which indicates the important role of MACC1 in carcinogenesis and CRC progression. Similar to these results, have been reported in previous studies. In conclusion, according to the results of this research and previous studies, the MACC1 gene can be considered as a biomarker for early detection of metastatic colorectal cancer.

کلیدواژه ها:

Colorectal Cancer ، MACC1 ، RT-PCR