Magnetic nanocomplex design for transferring cisplatin

The abundant use of platinum drugs, including cisplatin, has been associated with the development of cellular resistance in the treatment of various cancers. Theresilience of the cells leads to reduced efficacy, increased dosage of the drug, and ultimately increased side effects of the drug on normal cells and tissues. The purpose of this study is to transfer the drug using a magnetic nanocomplex to increase the effectiveness of the drug and subsequently reduce the dose of the drug. This nanocomplex was formed by attaching magnetic nanoparticles of iron oxide to a polyethylene amine cationic polymer and eventually adding the drug to it. The accuracy of the formation of the nanocomplex (magnetic nanoparticles-polyethyleneiminecisplatin) was evaluated using FTIR and DLS tests. Finally, the cell death rate induced by this nanocomplexcompared to the single drug (at the same concentration) on A2780 sensitive and resistant to cisplatin cells was investigated by MTT technique and IC50 of each treatment group was calculated. The results of the FTIR and DLS showed that nanocomplex magnetic is formed and its size is suitable for transmission. The results from the MTT test showed that the nanocomplex significantly induced cell death in the drug. Studies have shown that drug delivery with this nanocomplex regulates drug release in the cell, resulting in increased drug exposure and reduced resistance.

کلیدواژه ها:

Platinum drugs ، Nanocomplex ، Cisplatin