Analysis of Cerebrospinal Fluid in Diagnosis of Bacterial Meningitis; Using Nuclear Magnetic Resonance Spectroscopy:A Systematic Review
محل انتشار: علوم اعصاب کاسپین، دوره: 3، شماره: 10
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 479
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CJNS-3-10_006
تاریخ نمایه سازی: 18 اسفند 1397
چکیده مقاله:
Background: Analysis of biofluids provides a unique window into the biochemical status of a living organism since the composition of a given biofluid will be modulated according to the level of function of the cells that are intimately concerned with its manufacture and secretion. One of the most successful approaches to biofluid analysis has been the application of NMR spectroscopy.Objectives: The aim of this study was the survey of the role of Nuclear Magnetic Resonance (NMR) Spectroscopy in differential diagnosis of septic bacterial meningitis.Methods: Using the search strategy from three databases (MEDLINE/PMC, Web of Science, Scopus), list of references of selected articles and gray literature, without time and language limitation, articles up to March 2017 were entered into this review. In this review, 219 articles were acquired at the primary search. Study selection and quality assessment processes were done based on Cochrane library guidelines. After assessing the quality and inclusion and exclusion criteria, 4 articles were selected and entered into the data synthesis.Results: The results of 4 studies demonstrated relative elevation of lactate value and extracellular acidosis in bacterial meningitis not in aseptic meningitis. Moreover in most of them, decreasing its level by treatment was evident.Conclusion: Metabolomic analysis with NMR spectroscopy of cerebrospinal fluid can become a powerful helping in differentiation of septic meningitis from aseptic meningitis.
کلیدواژه ها:
نویسندگان
Alia Saberi
MD, Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Seyed-Ali Roudbary
MD, Neurology Department, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Mohamadreza Emamhadi
MD, Brachial Plexus and Peripheral Nerve Injury Center, Guilan University of Medical Science, Rasht, Iran
Samaneh Kazemi
MSc, Microbiologist, Vice-Chancellor of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran