Assessment of the effect Cinopar (Teriparatide) in the treatment of nonunion bone fractures

IntroductionNon-union is a clinical and treatment challenge for surgeons and specialists. Satisfactoryrepair of orthopedic fractures is so important for function and life quality of the patients.A way to achieve this goal is to use systemic treatment. This study aimed to investigate theeffect of Teriparatide on Non-union fractures.Material and MethodsA case series study conducted on 17 patients with Non-union fracture. A radiographicevaluation performed before the intervention. All x-ray images confirmed by a radiologistfor Non-union. Then all the patients underwent -3month treatment with Teriparatide.Finally, a control X-ray image conducted in order to assess the outcome. Data analyzed usingSPSS version 16.ResultsSixteen patients with nonunion fracture were evaluated in this study. Of this patients,nine individuals were male and eight were female. The mean age of the patients was20.51±45.18 years. The mean time past from the accident was 50 weeks. Femoral bonewas the most reported impaired place in our study. Out of the 16 patients who followed,recovery was seen in 10 patients(%62.5) with Cinopar .ConclusionIt is concluded that the treatment with Cinopar was effective to some extent. However,due to the few sample size of the study and also the loss of an accurate orthopedic andradiologic assessment as a nonunion cure index, the efficacy of Cinopar still remains unclear.

کلیدواژه ها:

Teriparatide ، Non-union fracture ، Bone healing