Association Between the MiRNA-152 Polymorphism and Risk of Preeclampsia in Pregnant Women

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 447

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

LAMOGMED03_142

تاریخ نمایه سازی: 21 بهمن 1397

چکیده مقاله:

Background: Preeclampsia (PE) is one of the well-known causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors have been suggested. MicroRNAs (like miR-152) are a small non-coding molecule which playing a role in a wide spectrum of biological processes such as cell proliferation and angiogenesis. This study aimed to test the possible relationship of polymorphism miRNA-152 rs12940701 and the risk of preeclampsia among the pregnant women in comparison with the control group.Methods: Genotyping of miR-152 rs12940701 was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women subjects by a polymerase chain reaction-restriction fragment length polymorphism method.Results: The results (in maternal blood) was shown an increase in T alleles for PE women, whoever there was not significantly difference between the PE and control group (OR: 1.7, P= 0.19). In addition, not significant difference was found in the C alleles between two groups (11.6% vs. 7%, OR: 1.4, P=0.3). Similarly, the results of polymorphism in placenta were repeated.Conclusions: We showed a lack of relationship between the polymorphism of miR-152 rs12940701 gene and preeclampsia development.

کلیدواژه ها:

Preeclampsia- miRNA152- Polymorphism- Gene

نویسندگان

Mohsen Rokni

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Mohsen Saravani

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran- Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Saeedeh Salimi

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran- Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Somaye Asghari

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran