Gene Expression Analysis of TNF and HNRNPL-Related Immunoregulatory Long Non-coding RNA (THRIL) in Iranian Patientswith Acute Myeloid Leukemia

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 293

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شناسه ملی سند علمی:

NSCMRMED03_184

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Recently, lncRNAs have been noticed asregulatory factors for several biological mechanisms throughmodulation of gene expression. Among them, the TNF and HNRNPLrelated immunoregulatory (THRIL) lncRNA may be implicated in thepathogenesis of immune-related and inflammatory disease throughregulating the expression of TNF-α.Methods: In this study, we assessed the expression of THRIL in the bloodof 25 acute myeloid leukemia (AML) patients in comparison to healthycontrols using real-time quantitative reverse transcription-PCR.Results: Results showed that there was no significant difference in theexpression level of THRIL lncRNA between AML patients and controlsubjects. Additionally, we did not find a significant association betweenmale subgroup and THRIL expression as well as females.Conclusion: In conclusion, our study demonstrated that THRIL cannotbe used as a reliable biomarker for AML diagnosis, although, the studyshould be confirmed by other studies.

نویسندگان

Iman Azari

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mohammad Taheri

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hamid Fallah

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Arezoo Sayad

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran