CHEMOPREVENTION OF AZOXYMETHANE-INITIATED COLON CANCER IN RAT BY USING A RESVERATROL

Background and Aim: Resveratrol is a stilbene substance, belonging to the superfamily of phytoalexins, which are abundant in red wine, red grapes, blueberries, peanuts and pistachios. it has been demonstrated that resveratrol has wide range of pharmacologic properties. It seems that additional biochemical and molecular activities of the compound can cause the effects of resveratrol in cancer and pre-cancer cellsMethods: The present study is designed to investigate the preventive effects of polymeric resveratrol on colon carcinogenesis in an azoxymethane-induced rat tumor. thirty rats were divided equally into healthy, control-and resveratrol-treated groups. Animals received azoxymethane (AOM) as a carcinogenic agent (15 mg/kg, s.c.) weekly for two consecutive weeks. They were given resveratrol (8 mg/kg, s.c.) two weeks before till 12 weeks after the last injection of AOM. In the end, histopathological and immunohistochemistry examinations were performed on colon tissueResults: The cytological and morphological changes of the cells healthy group were significantly lower compared to other groups that indicates the carcinogenous effect of azoxymethane medicine (P<0.05). Beta-catenin proteins expression was lower in the resveratrol group in compare-son with control group (P<0.05). In addition Axin expression was significantly increased in resveratrol in comparison with control -treated group (P<0.05)Conclusion: The present study demonstrated the potential anticancer effects resveratrol in a typical animal model. The results provide evidence that resveratrol exerts a significant chemopreventive effect on AOM-initiated colon cancer through cell proliferation inhibition

کلیدواژه ها:

Colon Cancer ، Resveratrol ، Beta-catenin ، Axin