ASSESSMENT OF THE EFFECT OF SAFFRON (CROCUS SATIVUS) ON THE LIVER FUNCTION AND LIPID PROFILE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 411
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شناسه ملی سند علمی:
INC15_528
تاریخ نمایه سازی: 30 دی 1397
چکیده مقاله:
Background and Aim: The aim of this study was to Assessment of the effect of saffron on the serum levels of liver enzymes and Lipid Profile in patients with non-alcoholic fatty liver disease (NAFLD).Methods: In this double-blind clinical trial,60 patients with the non-alcoholic fatty liver disease were randomly recruited to consume either 15 mg saffron extract (n = 30) or placebo capsules (n = 30) once a day for 8 weeks. aspartate and alanine aminotransferase, triglycerides, HDL-C and LDL-C were measured.Results: Statistical analysis showed that serum levels of triglyceride (p= 0.0008), aspartate aminotransferase (p= 0.03) and alanine aminotransferase (p= 0.0001) were significantly decreased in the saffron group. Moreover, changes in HDL-C and LDL-C levels were not statistically significant in the two groups.Conclusion: Saffron extract considerably improve liver functions and triglycerides levels in NAFLD patients in an 8-week randomized clinical trial. This might be considered as an adjunctive therapy alongside other treatments for NAFLD patients.
کلیدواژه ها:
نویسندگان
Narges Sadeghi
Msc Student of Nutrition Sciences,Nutrition Department, Paramedical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abazar Parsi
Assistant professor of gastroenterology, Alimentary Tract Research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Maria Torkashvand
Internal Resident, Alimentary Tract Research center, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran