THE EFFECT OF A HEALTHY NORDIC DIET ON CARDIOMETABOLIC MARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

Background and Aim: The healthy Nordic diet (ND), is supposed to be associated with a reduced cardiovascular risk; however, there are inconsistent results in the clinical studies. Using systematic review and meta-analysis of randomized controlled trials (RCTs), this study aimed to investigate the effect of the ND on cardiometabolic markers including plasma levels of total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol, and triglyceride (TG), as well as blood pressure in human adults.Methods: PubMed, Scopus, ISI Web of Science, and Google Scholar were systematically searched up to February 2018 for relevant articles. Random effects model was used to estimate the pooled mean differences in outcomes of interest.Results: Five RCTs consisting of 513 participants were included in the present review. The ND was associated with a significant reduction in systolic [weighted mean difference (WMD) = -3.97 mmHg, 95% confidence interval (CI): -6.40, -1.54, P = 0.001] and diastolic blood pressure (WMD = -2.08 mmHg, 95% CI: -3.43, -0.72, P = 0.003). The ND also significantly reduced the levels of total (WMD = -0.38 mmol/l, 95% CI: -0.76, -0.01, P = 0.044) and LDL cholesterol (WMD = -0.30 mmol/l, 95% CI: -0.54, -0.06, P = 0.013) compared with the control groups. However, no considerable difference in HDL cholesterol and TG concentrations was observed following the ND.Conclusion: The Nordic dietary pattern improves blood pressure and also some blood lipids, so it should be considered as a healthy dietary pattern.

کلیدواژه ها:

Nordic Diet ، Baltic Sea Diet ، Lipid Profile ، Blood Pressure ، Systematic Review ، Meta-analysis