ALPHA-LIPOIC ACID (ALA) SUPPLEMENTATION EFFECT ON CARDIO-METABOLIC PARAMETERS: RESULTS FROM A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 448
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شناسه ملی سند علمی:
INC15_484
تاریخ نمایه سازی: 30 دی 1397
چکیده مقاله:
Background and Aim: Several randomized clinical trials (RCTs) have investigated the effect of Alpha - Lipoic Acid (ALA) supplementation on cardio-metabolic parameters. However, the results were conflicting. Therefore, a meta-analysis, including randomized controlled trials (RCTs), was performed to assess the effect of ALA on some cardio metabolic parameters in adults with cardiovascular risk factors.Methods: A comprehensive, systematic literature search was done up to May 2018. From the eligible trials, 41 articles were selected for the meta-analysis. Two reviewers independently assessed the risk of bias and extracted data from included studies. Meta-analyses using random-effects model were used to analyze the dataResults: The result showed significant effect of ALA on FBS (WMD = - 6.57, 95% CI: -11.91 to -1.23, P = 0.016), HbA1C (WMD= -0.35, 95% CI: -0.55 to -0.15, P= 0.004), TNF-α (WMD = - 1.57, 95% CI: - 2.29 to - 0.85, P <0.05), IL-6 levels (WMD = - 1.15, 95% CI: -1.58 to - 0.72, P<0.001 and CRP (WMD = - 0.31, 95% CI: -0.47 to -0.16, P > 0.001) . No effect of ALA was detected in HOMA-IR and insulinConclusion: Alpha-lipoic acid treatment showed beneficial effects on some cardio- metabolicparameters. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on the cardio-metabolic parameters
کلیدواژه ها:
نویسندگان
Mehran Rahimlou
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Maryam Asadi
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nasrin Banaie
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran