EFFECTS OF BETA-HYDROXY BETA-METHYLE BUTYRATE (HMB), VITAMIN D, AND VITAMIN C- FORTIFIED YOGURT ON ANABOLIC, METABOLIC, INFLAMMATORY, AND OXIDATIVE STRESS BIOMARKERS IN SARCOPENIC ELDERLY

Background and Aim: sarcopenia, losses skeletal muscle mass, muscle strength and physical performance, is a common age-related disorder which is associated with metabolic disorders and progression to frailty. Dietary intervention is the best policy to manage sarcopenia health adverse outcomes. This study investigated the possible effect of yogurt fortified with HMB, vitamin D, and vitamin C on anabolic, metabolic, inflammatory, and oxidative stress biomarkers in elderly with sarcopenia.Methods: In a randomized, double-blind, placebo-controlled trial, 66 sarcopenic elderly received fortified yogurt (3 g HMB, 1000 IU vitamin D3, and 500 mg vitamin C) or plain yogurt for 12 weeks. Biochemical indexes including insulin like growth factor-1(IGF-1), homeostatic model assessment of insulin resistance (HOMA-IR), C-reactive protein (hs-CRP), malondialdehyde (MDA) were assessed at baseline and after 12 weeks of the study phase. Results: After 12 weeks of intervention, we found significant increase in serum 25-(OH) vitamin D (P=0.002), significant improvement in serum IGF-1 (P=0.042), significant reduction in serum hs-CRP (P=0.033) and serum MDA (P=0.008) in the intervention group compared with placebo group. However there were no significant changes in serum fasting insulin, fasting glucose, and insulin resistance (HOMA-IR) between intervention and placebo groups. Conclusion: Nutritional support with HMB, vitamin D, and vitamin C might improve anabolic condition related to IGF-1 availability and may possibly reduce inflammatory and oxidative stress levels.

کلیدواژه ها:

dietary intervention ، sarcopenia ، IGF-1 ، insulin resistance ، CRP