THE ASSOCIATION OF NECK CIRCUMFERENCE WITH RISK OF METABOLIC SYNDROME AND ITS COMPONENTS IN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background and Aim: Findings on the association between neck circumference (NC) and the risk of metabolic syndrome (MetS) are conflicting. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations.Methods: PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers. We included studies that examined the association of NC with risk of MetS, or at minimum, one of its components as outcomes. Results: Of 2628 publications identified, 19 papers met selection criteria. We found no association between NC and MetS (OR: 0.73; 95% CI:-0.003, 1.47). However, there was a positive association between NC and waist circumference (WC) (r =0.85; 95%: 0.75, 0.95; I2: 98.2%; p=0.0001), BMI: (r:0.88; 95% CI: 0.74, 0.91, I2:97.3%), triglycerides (TG) (OR: 1.87; 95% CI: 1.60, 2.19; I2:58.4%; p=0.03), TC (r:0.14; 95%CI: 0.05, 0.23, I2:94.1%), LDL-C (r: 0.18; 95%CI: 0.07, 0.29, I2:94.3%), hypertension (OR: 1.94; 95% CI:1.43, 2.64, I2:87.3%), low HDL-C (r:-0.21; 95% CI: -0.26, -0.15, I2=92.5%), as well as fasting blood sugar (FBS) concentrations (r: 0.20, 95%CI: 0.16, 0.24; I2:88.1%). Conclusion: Subjects with higher NC were at approximately two-fold higher risk for hypertriglyceridemia compared to those with lower NC. We found positive associations between NC, WC, BMI, hypertension, FBS, TC, LDL-C, and low HDL-C concentrations. However, due to high heterogeneity, findings should be taken with caution.

کلیدواژه ها:

Neck ، MetS ، cardio-metabolic risks ، adults ، meta-analysis