EFFECTS OF VITAMIN D-FORTIFIED YOGURT IN COMPARISON TO ORAL VITAMIN D SUPPLEMENT ON HYPERLIPIDEMIA IN PRE-DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

Background and Aim: The purpose of this study was to determine the effect of vitamin D-fortified yogurt consumption and its comparison with oral vitamin D supplementation in serum lipid profile in pre-diabetic patients with hyperlipidemia. Methods: This study was performed on 60 pre-diabetes patients who were randomly divided into two groups: group A (recipient of fortified yogurt with 1000 IU vitamin D) and group B (recipient of oral vitamin D supplement in a dose of 1000 IU) for three months. The study variables were evaluated at baseline and end of intervention. Results: The within-group analysis of lipid indices showed a significant reduction in the mean serum triglyceride levels in the fortified yogurt group (P = 0.001) and oral supplement group (P<0.001), Also, showed a significant reduction in mean serum total cholesterol, LDL-C (P <0.001) and HDL-C (P = 0.01) in both groups. The between-group comparison analysis of mean lipid indices changes showed that serum level of Triglyceride in oral supplement group were significantly more than fortified yogurt group (P=0.03). However, no significant difference was observed in the mean changes in serum TC (P=0.63), LDL-C (P=0.93) and HDL-C (P=0.21) levels between the oral supplement group and the fortified yogurt group.Conclusion: Fortified yogurt is a better alternative strategy of supplement to reduce the prevalence of vitamin D deficiency and consequently to improve the serum lipid profile in hyperlipidemic individuals.

کلیدواژه ها:

Vitamin D fortified yogurt ، Vitamin D deficiency ، Hyperlipidemia ، Vitamin D supplement ، Pre-diabetes ، Iran