LOW GLYCEMIC LOAD OR INDEX DIET IN ASSOCIATION WITH ACNE VULGARIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background and Aim: Acne Vulgaris (AV) is known to be a multi-factorial skin disorder which affects the social life of affected people. Dietary factors and especially glycemic indices are regarded to be associated with AV. Different finding in the studies led us to investigate the effect of glycemic index (GI) of food and glycemic load (GL) of diet on AV through a systematic review and meta-analysis.Methods: PubMed, EMBASE, Scopus, and Google Scholar were searched for clinical trials and observational studies. The mean ± SD for acne grading in trial clinical trials and the mean ± SD GI or the GL of the diet for observational studies were used for meta-analysis.Results: Nine out of Fifteen studies were eligible for systematic review in both clinical and observational designs (3 and 6 studies, respectively), included in quantitative analysis. Three studies clinically assessed the effect of GI/GL on acne and showed that a diet with lower GI/GL reduces the acne severity (Hedges’g= -0.91, 95%CI:-1.57,-0.25, p=0.007). Subgroup analysis of the 6 observational studies showed dietary habit with higher GI might not affect acne severity in acne patients (Hedges’g= 0.07, 95%CI: -0.23, 0.38, p= 0.636), but individuals with higher acne severity consume diet with higher GL (Hedges’g= 0.64, 95%CI: 0.01, 1.26, p= 0.045).Conclusion: Diet, as a part of the lifestyle, is associated with AV. Concordance to the lower GL diet and using may reduce the severity of AV. Further well-designed studies are required to confirm these results.

کلیدواژه ها:

Acne Vulgaris ، Glycemic Index ، Glycemic Load ، Diet ، Systematic review ، Meta-analysis