EFFECT OF PROBIOTIC SUPPLEMENTATION ON CD4 CELL COUNT IN HIV-INFECTED PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

controlled trials (RCTs) of probiotic/prebiotic/synbiotic supplementation on CD4 cell counts in HIV-infected patients Methods: A systematic search of RCTs was conducted through PubMed, Scopus, and Google Scholar databases up to August 2015. Effect sizes of eligible studies were pooled using random-effects models (the DerSimonian-Laird estimator).Results: Eleven studies with 14 treatment arms met the inclusion criteria. Pooled analysis showed no signifcant reduction in CD4 counts (−7.5 mg/l, p =0.7) in intervention-treated individuals. Subgroup analysis on potential influencing factors highlighted sex, country of origin, study duration, and the type of intervention as having signifcant effects on CD4 cell counts.Conclusion: As a whole, the results of this meta-analysis suggested that supplementation with probiotic may not change CD4 counts. However, a signifcant increase in CD4 counts was seen in females and following synbiotics as opposed to treatment with pro- or prebiotics alone

کلیدواژه ها:

CD4 cell ، HIV/AIDS ، prebiotic ، probiotic ، synbiotic