ASSOCIATION OF DIETARY INFLAMMATORY INDEX WITH COMMON MENTAL HEALTH DISORDERS PROFILE

Background and Aim: The association between diet and mental health disorders might be mediated by inflammatory properties of diet. We evaluated the association of dietary inflammatory index (DII) with the risk of worse mental health disorders profile.Methods: A total of 3363 Iranian adults were included in this cross-sectional study. Mental health disorders profile’ score was calculated using regression method in the framework of factor analysis based on anxiety, depression and psychological distress. The higher scores of mental health disorders profile indicates more severity of mental problems. Twenty-seven nutrients, onions, tea and caffeine were included in the calculation of DII. The higher scores of DII indicated a pro-inflammatory diet. The odds of being in the highest tertile of mental health disorders profile across the tertiles of DII was assessed using multinomial logistic regression.Results: Either in the crude or full-adjusted multinomial logistic regression models, participants in the lowest tertile of DII had lower risk for being in the top tertile of mental health disorders profile (adjusted model: OR: 0.45; 95% CI: 0.33, 0.60). In the stratified analysis by sex, similar findings were observed in both genders though the associations tended to be marginally significant in men (in male: OR: 0.53; 95% CI: 0.31, 0.90; P trend=0.070, and in female: OR: 0.40; 95% CI: 0.27, 0.58; P trend<0.0001).Conclusion: Our findings suggest a direct association between the pro-inflammatory properties of diet and increased risk of higher mental health disorders profile scores. Clinical trials are required to confirm this finding.

کلیدواژه ها:

Dietary inflammatory index ، mental health ، depression ، anxiety ، distress