THE ASSOCIATION BETWEEN DIETARY ANTIOXIDANTS AND ADIPOKINES LEVEL AMONG OBESE WOMEN

Background and Aim: Adipokines are associated with several oxidative stress-related diseases and pathologic conditions. We aimed to assess the association between antioxidants and adipokines in obese adults. Methods: In this cross-sectional study, a total of 160 obese women were included. Body composition and anthropometric characteristics were measured. Dietary intakes were assessed by 3-day, 24-h dietary recall. Blood samples were obtained following an overnight fasting. Serum concentrations of adipokines including progranulin, retinol binding protein 4 (RBP4) and Angiopoietin-related growth factor 6 (ANGPTL6) was measured using enzyme-linked immunosorbent assay. Results: Mean age and BMI of women were 39.31 and 35.05, respectively. There was a positive significant association between ANGPTL6 and vitamin D intake (p<0.001). Also, there was marginally association between RBP4 and vitamin A (p=0.063) intake, but after adjustment age, and fat mass, we found a significant association (p=0.008). However, the associations between dietary antioxidants, progranulin, and ANGPTL6 were not statistically significant.Conclusion: ANGPTL6 and RBP4 levels directly associated with dietary vitamins D and A intake, respectively. But, according to the results the association between ANGPTL6 and vitamin D was bidirectional. The suggested associations probably can be useful in the development of interventional studies for management of chronic diseases.

کلیدواژه ها:

Antioxidants ، ANGPTL6 ، RBP4 ، progranulin ، Adipokines ، Obesity