HIGHER DIETARY TOTAL ANTIOXIDANT CAPACITY IS RELATED TO PRE-DIABETES: A CASE-CONTROL STUDY

Background and Aim: Dietary total antioxidant capacity (DTAC) is recognized as a useful tool for measurement of antioxidants intake. So far, the association between DTAC and the blood glucose status has been studied mostly among the healthy subjects. The aim of our study was evaluate the association of DTAC and pre-diabetes in a case-control design. Methods: We included 300 subjects with (n=150) and without (n=150) pre-diabetes who attended a Diabetes Screening Center in Shahreza, Iran. The anthropometric data, physical activity, and blood glucose level of were measured from all participants. Data on dietary intakes were determined by the validated 168-item FFQ, and DTAC was computed using the USDA database. Logistic regression was performed to assess the relationship between sex-specific and energy adjusted DTAC and pre-diabetes morbidity.Results: the pre-diabetic subjects had less DTAC as compared with the control group (p<0.001). The subjects at higher quartiles of DTAC had lower fasting blood glucose and 2-hour post-challenge plasma glucose (p-trend <0.02). After controlling for BMI, physical activity, education, dietary intake of fiber, fat, energy and coffee, subjects in the highest quartile of DTAC were less likely to experience pre-diabetes in comparison to the first quartile (OR 0.18, 95% CI 0.07-0.49).Conclusion: Our finding suggests that DTAC is a useful tool for understanding the relationship between diet and pre-diabetes morbidity. Future studies are recommended to confirm these results in other populations.

کلیدواژه ها:

dietary total antioxidant capacity ، antioxidant ، oxidative stress ، fasting blood sugar ، prediabetes ،