THE EFFECTS OF GINGER SUPPLEMENTATION ALONG WITH NON-SURGICAL PERIODONTAL THERAPY ON INFLAMMATORY, ANTIOXIDANT, AND PERIODONTAL PARAMETERS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CHRONIC PERIODONTITIS. A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Background and Aim: Diabetes mellitus (DM) and periodontitis are two common chronic diseases with bidirectional relationship. Oxidative stress plays a key role in pathogenesis of these two diseases. The aim of this study was to evaluate the effects of ginger supplementation in adjunct with non-surgical periodontal therapy (NSPT) on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP). Methods: In this double-blind clinical trial study, 50 T2DM patients with CP were randomly allocated to intervention and control groups and received either 2 gr ginger or placebo (4 tablets) twice a day for 8 weeks. All patients were treated with NSPT during the intervention period. Serum levels of interleukin-6 (IL-6), superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), pocket depth (PD) and plaque index were evaluated in all subjects pre-intervention and post-intervention.Results: A significant reduction (p < 0.05) was observed in the mean levels of IL-6 and PD in the intervention group post- intervention. The mean serum level of SOD and GPx was significantly increased in the intervention group after the intervention (p < 0.05). There were significant differences in the mean changes of GPx, IL-6, and PD between intervention and control groups after the intervention (p < 0.05). Conclusion: It is recommended that ginger supplementation along with NSPT may be effective in controlling the inflammatory, antioxidant, and periodontal parameters in T2DM with CP.

کلیدواژه ها:

Type 2 diabetes mellitus ، Periodontal disease ، ginger ، Inflammation ، antioxidant enzymes