Three-component synthesis of spiro[indole-pyrimidine]one derivatives and evaluation of their antibacterial activity

Facile and efficient synthesis of spiro[indole-pyrimidine]ones by three-component reactions of phenacylidenetriphenylphosphoranes, oxindoles and thiourea. in presence of chloroacetic acid as catalyst is described. This ecofriendly protocol offers several advantages such as a cost-effective procedure with excellent yield, short reaction time, good functional group tolerance, and broad scope of usable substrates. Antibacterial activity of one of synthesized compounds (4j), minimum bactericidal concentration (MBC) was evaluated against against Gram positive S. aureus and B. subtilis and Gram negative E. coli and P. aeruginosa at different concentration. The results showed that the compounds 4j was shown strong antibacterial activity at concentration 0.05 mg ml-1 against Gram-negative and Gram negative bacteria.

کلیدواژه ها:

Spiro[indole-pyrimidine]ones ، Three -Component reactions ، Phenacylidenetriphenyl phosphoranes ، Oxindoles ، Antibacterial activity