A Simple, Convenient and Eco-Friendly Method for the Synthesis of 2,4,5-trisubstituted-1H-imidazoles Catalyzed by Vitamin B12 Under Solvent-Free Conditions

A simple, highly efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles via one-pot three component condensation of benzil, aldehydes and ammonium acetate under solvent-free conditions has been achieved utilizing vitamin B12 as catalyst. This methodology has number of advantages such as: use of green and nonhazardous catalyst, clean work up, solvent-free conditions, short reaction times, high yields and no need to column chromatography.

کلیدواژه ها:

Imidazole ، Vitamin B12 ، Three component reaction ، Solvent-free