Comparing the effect of dill seed and clotrimazole vaginal creams on vulvovaginal candidiasis: a clinical trial

Introduction: Vulvovaginal candidiasis (VVC) is a very common debility in gynecologic clinics. Despite access to several antimycotic agents,VVC is still a challenge,so presenting a novel antimycotic agent especially with a traditional origin is of interest and demanded. Dill seed has been used as a vaginal discharge remedy according to traditional origins. The aim of this study was comparing the Anethumgraveolens L. (Dill) vaginal cream efficacy with that of clotrimazole vaginal cream 1 % to treat VVC.Methods: In this study, married women aged 18-65,with probable VVC were enrolled for primary evaluation. After VVC confirmation by sniff test, the patients were allocated into 3 groups. The first group (n=59) was treated with clotrimazole vaginal cream 1%; the second159(n=60) with combination of dill seed aquaes extract-essential oil vaginal cream 2%; and the last (n=56) with dill seed essential oil vaginal cream 2% for 7 nights. After 10 days, the therapeutic effects were assessed. The data were analyzed by SPSS v. 20 through chi-square,McNemar,Kruskal-Wallis,and Wilcoxon tests.Results: Although a statistically significant difference according to the main clinical symptom (itching) was revealed among the 3 groups (p = 0.00),there was no significant difference between dill seed total extract and essential oil vaginal creams (p= 0.06). Also no significant adverse reactions were reported in the groups (p> 0.05).Conclusion: This study showed this herbal vaginal cream could be used as an alternative anti-mycotic therapy for VVC.

کلیدواژه ها:

AnethumgraveolensL. ، Antimycoticherbal vaginal cream ، Traditional medicine ، Vulvovaginal candidiasis