Study of Prevalence and antimicrobial susceptibilities of Methicillin resistant Staphylococcus aureus bacteremia in hospitalized patients in Shiraz, Iran

Introduction and Objectives: Methicillin resistant Staphylococcus aureus (MRSA) is one of the major morbidity and mortality of hospital infections. In this study, we evaluated the prevalence and antibiotic resistance of MRSA, isolated from blood culture in shiraz. Materials and Methods: A retrospective study was carried to identify the prevalence of MRSA in the blood culture isolates and their antibiotic susceptibility patterns in Nemazee Teaching Hospital from March 2014 to August 2018. S. aureus were isolated by automated blood culture system and identified by standard biochemical methods. Antibiotic susceptibility testing was performed by Kirby Bauer Disk Diffusion method according to the Clinical and Laboratory Standards Institute guidelines. Methicillin resistance was detected using cefoxitin (30 μg) disc. Screening of clinical S.aureus isolates for vancomycin resistance was done on brain heart infusion agar containing vancomycin, 6 mg/mL. Results: In our study, out of 321 S. aureus, 45% were MRSA. All the strains were sensitive to Linezolid and Vancomycin. The strain were highest resistant to Penicillin and Cephalexin.Conclusions: According to the results and high rate of MRSA, regular surveillance studies in different hospitals and centers is necessary to take adequate measures to prevent and control spreading of resistant strains.

کلیدواژه ها:

Methicillin resistant ، Staphylococcus aureus ، Antibiotic Resistance ، bacteremia ، Shiraz