Toxigenic Clostridium difficilein Hospitalized Patients

Background and Objectives: Clostridium difficile is one of the most common nosocomial bacteria in the industrial nations and the main etiological agent of antibiotic-associated diarrhea and pseudomembranous colitis. Most people that develop disease symptoms have undergone antibiotic treatment. Diarrhoea illnesses are a relatively frequent side effect of antibiotic therapies.The aim of this study was to assess the detection of pathogenic toxin A/B-positive Clostridium difficilestrains among hospitalized patients with diarrhoea in Gonabad, Iran.Materials and methods: In this research hospitalized patients submitted to 22Bahman hospital (Gonabad, Iran) and if they had a liquid stool specimen were included. A total of 50 consecutive unformed or liquid feces samples from hospitalized patients were obtained for inclusion in this study. Stool samples were collected and Clostridium difficile toxin A/B immunoassay was performed according to manufacturer guidelines.Results: In present study, total 50 patients with liquid stool sent for Clostridium difficile toxin A/B assay were enrolled in the study. Patients consisted of 18 males (36%) and 32 females (64%). Maximum number of cases were in the age group of less than 10 years (n=29, 58%). Among the studied patients, 16 (32%) cases were positive for Clostridium difficile toxin A/Bby immunochromatographic assay. Analysis of data revealed that frothy-four (88%) patients received on or more antibiotic treatment on admission and hospitalization (17 patients: ceftriaxone, 3 patients: metronidazol, 3 patients ciprofloxacin, 3 patients: ceftriaxone + metronodazol).Conclusion: Diagnostic of pathogenic Clostridium difficile can improve the handling of infection and may lead to a more reasonable use of antibiotics, as the physician will rapidly obtain the clinical microbiology results. As a result, we need to refocus our prevention and management protocols.

کلیدواژه ها:

DiarrheaToxigenic Clostridium difficile ، Hospitalized patients ، Stool antigen