In Vitro Activity and Comparison of Tedizolid with Linezolid and Teicoplanin against Vancomycin-Resistant Staphylococcus aureus Strains
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 449
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شناسه ملی سند علمی:
ICCM12_014
تاریخ نمایه سازی: 1 دی 1397
چکیده مقاله:
Introduction and Objectives: Staphylococcus aureus is considered as a normal flora by colonization in the nose and skin of humans, yet it is as a major cause of nosocomial infections and a life-threatening pathogen. As the second-generation of Oxazolidones, tedizolid has displayed potent activity against Gram-positive pathogens. The aim of the present study was to determine the frequency and comparison of the minimum inhibitory concentration of tedizolid with linezolid and teicoplanin against the vancomycin-resistant S. aureus isolates .Materials and Methods: This study was done on specimens isolated from hospitalized patients (n = 125) in Golestan province during 2017-2018. After identifying of S. aureus isolates using specific tests, broth microdilution test was used according to CLSI M100-S25(2015) criteria to determine the minimum inhibitory concentration(MIC) of antibiotics.Result: The frequency of vancomycin-resistant S. aureus isolates was 31.4%. Determining MIC of tedizolid showed that all isolates of S.aureus tested were susceptible to tedizolid (MIC, ≤0.5μg/mL), while 95% (MIC, ≤4μg/mL) and 89% (MIC, ≤8μg/mL) of isolates were categorized as susceptible to linezolid and teicoplanin, respectively. The concentration of tedizolid that inhibited 90% of isolates (MIC90) was 0.5μg/mL, 4-fold lower than linezolid(MIC90=2μg/ml) and 16-fold lower than teicoplanin (MIC90= 8μg/mL). There was a significant difference between the frequency of drug- resistance of strains isolated from skin and bone infections, so 94% of teicoplanin- resistant isolates and all strains resistant to linezolid were isolated from patients with bone infections (P<0.05).Conclusion: We conclude that tedizolid has a beneficial effect on clinical isolates of S. aureus, and possesses more potent in vitro activity than the rest agents.
کلیدواژه ها:
نویسندگان
Leila Fozouni
Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Zahra Pishdad
Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Bahar Abdollahi
Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran