The study of prevalence and antibiotic susceptibility of Clostridium difficile in ICU patients in Bahonar hospital, Kerman, 2015-2016

Introduction and objectives: Hospital acquired infection is now one of the major problems of hospitalized patients. Clostridium difficile Associated Diseases (CDAD) is consider one of the major types of nosocomial infection. The prevalence of C. difficile infection and its relation with the type of antibiotics and length of hospitalization were evaluated among admitted patients at the ICU of Kerman Bahonar hospital. The antibiotic sensitivity patterns of isolated C. difficile were also performed.Methods: The patients‟ stool samples with antibiotic associated diarrhea were collected. Then C. difficile isolated and identified by standard methods and their sensitivity to the different types of antibiotics were examined by disk diffusion agar technique.Results: C. difficile was isolated from 134 out of total 385 samples. It is also revealed that there is a significant correlation between incidence of CDAD with the kind of consumed antibiotics and the length of hospitalization (P<0.05). But there were not found any correlation among age, sex and appearance of the infection. The results also show all of isolated C. difficile were sensitive to vancomycin, chloramphenicol and ceftriaxone and they were resistant to kanamycin and gentamicin.Conclusion: It was found from the study results, C. difficile should be consider as one of the major agents that cause the hospital acquired infection especially at the ICU. The policy of health authority should be also directed to reduce the length of staying the patient at the hospital.

کلیدواژه ها:

Clostridium difficile ، Hospital acquired infection ، Intensive Care Unit ، Antibiotic sensitivity ، Kerman