The prediction of miR-199a, miR-199b, and miR-30c role in dopaminergic cell death pathways in Parkinson’s disease

MicroRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at the posttranscriptional level. The role of miRNAs in the maintenance of normal cellular functions and in disease-inducing pathways has been increasingly demonstrated. miRNAs play important roles in neuronal patterning and cell differentiation. miRNAs also have been reported to be involved in neurodegenerative disorders including Parkinson’s disease (PD). PD is the most prevalent movement disorder characterized by selective loss of midbrain dopaminergic neurons. In this study, network-based systems biology tools including Pathway Studio 9.0 and 3Omics were used to identify PD critical molecular players. Utilizing currently available and frequently used computational tools for miRNA target prediction,i.e., PicTar, TargetScan, DIANA-microT, miRanda and miRWalk2.0 databases to predict miRNA-mRNA interaction, we investigated probable interaction of miRNAs and genes that participate in dopaminergic cell death pathways in PD. we have predicted possible role of three miRNAs miR-199a, miR-199b, and miR-30c which could control dopaminergic cell death pathways in PD so possibly effect on PD onset and progression. several therapeutic approaches may be considered for these miRNAs besides of their application as a valuable prognostic or diagnostic biomarkers in PD.

کلیدواژه ها:

MicroRNA ، Parkinson’s disease ، Dopaminergic neurons