Evaluate the Effect of Colloidal Silver Combinated to Recell Technique on Wound Healing

Background: Recell technique is a new methods for the first and second-grade wound healing. Method of this technology is producing cell suspension from patient s skin, which is a safe, and sprayed into the wound. The use of colloidal silver is important for wound healing beacuse of antimicrobial effect on wound. The aim of this study is to compare efficacy of recell technique and silver colloidal on wound healing. Methods: This review article was carried out by searching for studies in Pubmed, Embase, Scopus and Cochrane library (from inception to Mar 2018), by using the search terms recell silver nanoparticle wound healing and silver colloid . The search was limited to articles published in English. In this review, 310 articles that are associated with subject, were found and of these, 32 articles were applied. Results: The cells, which were converted to suspension by Recell machine, have free edge. And they causes wound healing by produce interluekine-1 (IL-1) and proteins (such as HSP90 and HMGB1) after about 5 to 7 days.This technique has greatly reduced the scarring and the effects of skin grafts, especially on burns. Silver colloidal have broad-spectrum antibacterial efficacy, reducing inflammation by regulate cytokines (include reducing MMP9, IL6 and increasing VEGF, IL10, INFγ) and stimulating the migration and proliferation of keratinostattites, activating macrophages that resulting in wound healing and repair it. Conclusion: Considering the antimicrobial role of silver nanoparticles, it can be considered as complementary to Recell s technique. Colloid silver assumes the role of reducing the infection of wound. So, the combination of these two techniques can be used to treat wound healing better.

کلیدواژه ها:

Wound Healing ، Recell ، Colloidal Silver ، Anti-inflammatory Effect ، Anti-microbial Activity ، Cytokine