Role of Entegrins in Wound Repair and its Periodontal Emplications
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 425
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شناسه ملی سند علمی:
WTRMED05_006
تاریخ نمایه سازی: 5 آذر 1397
چکیده مقاله:
Wound healing in human periodontium is a complex process which involves both cell-cell and cell-matrix interactions. Entegrins play a major role in regulation of these cell-cell, cell-matrix interaction. Wound healing involves two major events i.e. re-epithelialization and connective tissue repair. In this concise review, we will discuss the role of integrins in these major events as well as their impIications in periodontal wound repair. Entegrins are differentially expressed in both of these major events. In re-epithelialization, keratinocytes express novel integrins receptors alphavB1, alpha5B1and alphavB6 which are not expressed in normal healthy epithelium. Re-epithelialization also involves interaction of integrins with TGF-B and fibronectin. Similarly, in connective tissue repair, the activation of fibroblast as well as the expression of integrins alpha5B1 and alpha3B1 is upregulated. In healthy periodontium, integrin alphavB6 is normally expressed in junctional epithelium which is generally expressed only at wound sites in other parts of the body. The epithelialization at implant surface has not been yet fully explored with respect to interactions among integrins and other extra-cellular matrix molecules.
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نویسندگان
Asadi Asadi
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
Ahmad Rahimi
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
Elahe Mohtasham
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran
Raha Latifi
PHD, Assistant Professor of Nursing, Isfahan university, Isfahan, Iran