Assessment of Hormonal, Sperm Head Abnormality and Histopathological Activity of Ranitidine Drug (Zantac) on Albino Male Mice

The purposes of this study are to determine the effect of Zantac (Ranitidine) drug on sexual hormones (Testosterone and Prolactin), sperm head abnormality, and histopathological activity on albino male mice testes.Two doses of the drug were used which included: (1000 and 2000mg/kg) of Zantac drug in additional to negative control in mice. Each group include four mice and the drug were administrated orally as a single dose (0.1 ml) per a day and for 14 days, and then the mice were sacrificed on the day 15 for laboratory assessments. The result showed that the drug cause increase the percentage of sperm head abnormality which reach to (48.3%) and (22.8%) for 2000mg/kg and 1000mg/kg respectively in comparison to control group (11.1%). The male sexual hormones also effected by the drug and the level of testosterone hormone decrease to (1.07ng/ml) in 2000mg/kg and (3.42ng/ml) in 1000mg/kg, while the level of hormone in control group is (14.07ng/ml). The prolactin hormone show increase in the level at dose 2000mg/kg its (115ng/ml) and in dose 1000mg/kg the level its (43ng/ml) these value very high compared with control group (36ng/ml) due to effected of the drug on hormone. The histopathological examination show damage in the seminal duct and changes in the wall of seminiferous tube also the spermatogenesis well be effected by the drug in which is stop and some of seminal duct show no appearance of spermatogenesis and also cause depletion to the wall of seminal duct.