Beneficial effect of Fumaria officinalis on recovery of glomeruli in renal tissue of diabetic rats

Background and Objective:Diabetes mellitus is a common metabolic disorder in societies that can lead to some defectssuch as nephropathy. Investigations show that diabetic nephropathy is the most importantreason of morbidity and mortality in diabetics. One of the complications of diabeticnephropathy is distention and destruction of glomeruli in renal tissue. According to variousreferences to Fumaria officinalis in traditional medicine, this study was conducted to surveythe effect of this plant on arrangement of glomerular renal tissue of male rat in diabetic state.Materials and Methods:In this experimental investigation, 32 male Wistar rats, weighing 200-250 g, were dividedrandomly into 4 groups: 1.control, 2. control receiving treatment with FO, 3. diabetic, and 4.diabetic receiving treatment with FO. Diabetes induced by intraperitoneal injection ofStreptozotocin (60mg/kg). Groups under treatment received food containing 6.25% of FO. Todevelop awareness of diabetes, blood sample was acquired from rats, first one week after theinjection and then 6 weeks after the injection. Then the rats were anesthetized, the kidneyswere removed by opening the peritoneal cavity. After making sections and microtome cutparaffin blocks, glomerular morphology was observed using Hematoxylin and Eosin stain.Quantifiable data resulted, was analyzed with one-way ANOVA in the SPSS v: 19 software.Findings:Although diabetic rats showed an expansion and some cellular dispersion in marginal areas ofglomeruli, but glomerular diameter was not significantly higher than control group. Inaddition, FO treatment of diabetic rats non-significantly improved these changes.Conclusion:Fumaria officinalis treatment of diabetic rats could in part protect renal glomeruli and thismay be of clinical significance in diabetic nephropathy.

کلیدواژه ها:

Fumaria officinalis ، Diabetes mellitus ، Renal tissue ، Rat