STUDY THE PREVALENCE OF RESISTANCE GENE, QACE TO QUATERNARY AMMONIUM COMPOUNDS IN THE ISOLATED ACINETOBACTER BAUMANNII OF HOSPITAL OF QAZVIN (2015-2016)

Background and Aim:Acinetobacter baumannii is one of the important agent of hospital infections. In recent years, there are several report about frequency of resistant acinetobacter against quaternary ammonium compounds (QACs) in the clinical unit of hospitals in the world. It has used different antiseptics and disinfectants for preventing hospital infections in clinical centers and hospitals. QACs like benzalkonium has widely used as wound and skin antiseptic and hospital disinfectant. The mechanism of resistance to disinfectants was happened by resistance genes type qacE that was isolated from gram negative bacteria. As the importance of preventing hospital infection due to acinetobacter, the aim of this study, was to determine prevalence of resistance gene, qacE to disinfectant in the clinical isolated acinetobacter baumanniiMethods: Totally, 141 isolated acinetobacter baumannii were studied from specimens of hospital of Qazvin Province from Sep 2015 for year. The isolated were characterized as acinetobacter baumannii via standard methods. Then, all isolated were studied using polymerase chain reaction (PCR) and sequencing for qacE resistance geneResults:Isolated acinetobacter of trachea, urine, and blood were 82(58%), 23(16%), 14(9%) respectively from all specimens. Also, 24 (17%) isolated have qacE gene and the most frequency of isolated acinetobacter baumannii that contain qacE gene were in ICU 14(58%). The result of this study showed the significant resistance to disinfectants in the evaluated hospitalsConclusion:Thus, more attention to acinetobacter baumannii as an important agent in the hospital infection and applying disinfectant is necessary

کلیدواژه ها:

Acinetobacter baumannii ، Quaternary ammonium compounds ، qacE gene