Improvement of Acetaminophen solubility in supercritical carbon dioxide Using Menthol cosolvent

In this work, the effects of Menthol cosolvent addition on the solubility of Acetaminophen (AC) in supercritical carbon dioxide (SC-CO2) were investigated at temperature 313 K for pressures from 100 to 250 bar. Measurement of solubility values under different pressures revealed that Menthol enhances the solubility of AC significantly. The experimental data are useful to the production of ultra fine AC particles by RESS-SC method.

کلیدواژه ها:

Acetaminophen ، Menthol ، solubility ، poorly soluble drug ، supercritical carbon dioxide