Protective Effects of Carvacrol and Thymol in hypertrophied rat hearts
محل انتشار: ششمین کنگره بین المللی نارسایی قلب ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 584
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شناسه ملی سند علمی:
HFMED06_007
تاریخ نمایه سازی: 26 مرداد 1397
چکیده مقاله:
Cardiac hypertrophy markers: •blood pressure•the heart weight to body weight ratio•Collagen deposition •ANP and BNP mRNA levels •and apoptotic rate •diverse pharmacological properties of carvacrol and thymol: •antioxidant, antimicrobialand anti-inflammatory •Cardiovascular effects such as vasorelaxation and hypotension ialsandmethods MaleWistarratsweredividedintosixgroups(n=10). Intactanimalsservedasthecontrolgroup(Ctl). Hgroup: Toinducehypertrophymodel, animalsunderwentabdominalaortabanding.Car25+Hgroup Thy10+Hgroup AgroupofanimalstreatedsimultaneouslywithCarvacrolandThymol(Car+Thy).The superoxidedismutase (SOD)activity,Malondealdehyde(MDA)levelandthefreeradicalscavengeringactivity(DPPH)alsowereestimatedbybiochemicaltests. intheHgroup,systolicanddiastolicbloodpressurewereincreasedsignificantlyincomparisonwithCtlgroup(P˂0.001)•Intreatmentgroup sthebloodpressureandtheheartweighttobodyweightratioweredecreasedincomparisonwithHgroup.•.CarvacrolincombinationwithThymoldecreasesANPandBNPmRNAlevelssignificantlyincomparisonwithHgroup.•InCar+HandCar+Thygroups, theSODactivitywereincreasedsignificantlyincomparisonwithHgroup.•tissueMDAlevelwasdecreasedradically comparedtothegroupHinalltreatmentgroupsandDPPHradicalscavengingactivitywasincreasedinThy+HandCar+ThygroupscomparedtothegroupH.•Conclusions:administrationofCarvacrolincombinationwithThymoldecreasesmyocardialhypertrophymarkersviaaugmentationofantioxidantcapacityinratsfollowingtheabdominalaorticbanding.
نویسندگان
Mohabbat Jamhiri
HerbalMedicineResearchCenter,ShahidSadoughiUniversityof MedicalSciencesandHealthServices,Yazd,Iran
Fatemeh Safari
HerbalMedicineResearchCenter,ShahidSadoughiUniversityof MedicalSciencesandHealthServices,Yazd,Iran
Zeinab Hafizibarjin
HerbalMedicineResearchCenter,ShahidSadoughiUniversityof MedicalSciencesandHealthServices,Yazd,Iran
Mojtaba Ghobadi
HerbalMedicineResearchCenter,ShahidSadoughiUniversityof MedicalSciencesandHealthServices,Yazd,Iran