Melamine trisulfonic acid as a highly efficient catalyst for the synthesis of polyhydroquinolines under solvent-free conditions

A highly efficient, simple and clean solvent-free protocol for the synthesis ofpolyhydroquinolines is described. The one-pot multi-component condensation reaction betweenarylaldehydes, dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammoniumacetate in the presence of 2.5 mol% of melamine trisulfonic acid (MTSA) at 60 °C affords thetitle compounds in high yields (83-98%) and short reaction times (3-30 min).

کلیدواژه ها:

Polyhydroquinoline ، melamine trisulfonic acid (MTSA) ، solvent-free ، arylaldehyde ، dimedone (5 ، 5- imethylcyclohexane-1 ، 3-dione) ، β-ketoester