Three-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3- dipolar cycloaddition

The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library ofspiropyrrolizidineoxindoles via a four-component 1,3-dipolar cycloaddition reaction ofazomethine ylides, derived from isatin, with electron-deficient dipolarophile was described. Theprocess occurs at room temperature in aqueous ethanol as a green solvent and in the presence ofa bidendatebis(imine)–Cu(II)triflate complex as efficient catalyst.

کلیدواژه ها:

Chiral auxiliaries ، chiral spiro-oxindolopyrrolizidines ، asymmetric 1 ، 3-dipolar ، azomethineylide ، three-component reaction ، MCRs ، proline ، sarcosine