Protective Effect of Aloe Vera Extract Against Bisphenol A- Induced Poly Cystic Ovary Syndrome in Wistar Rats

Background: Bisphenol A (BPA), an environmental pollutant, affects the reproductive health of wildlife and possibly of humans because it induces ovarian toxicity. BPA can induce poly cystic ovary syndrome. Thus, the aim of the present study was to investigate if BPA induces oxidative stress and hormonal disorder in the ovary of rats and if coadministration of Aloe vera extract, can prevent adverse effects.Materials and Methods: In this experimental study forty adult female Wistar rats (200 ± 20 g) were divided into 5 groups. Group1 control; group2 vehicle (5ml/kg b.wt./day); group3 (400 mg Aloe vera gel/kg b.wt./day); group4 (10 mg BPA/kg b.wt./day,dissolved in 5ml/kg olive oil); group5 (BPA+ Aloe vera), daily and orally for 8 weeks. At the end of the study, the rats were anesthetized and 2 ml blood samples were obtained for evaluation ofsex hormones and oxidative stress markers. Also, both ovaries were collected for histological examinations. Results: BPA significantly decreased estradiol (P<0.05). Malondialdehyde (MDA) incresed, thiol protein (G-SH) and total antioxidant capacity (TAC) decreased. Histopathological results of BPA group showed fewer corpus luteum and antral follicles, more atretic follicles and several cysts. But, co-administration of Aloe vera with BPA accelerated the total antioxidant capacity and ovarian tissue structure healing. Conclusion: Given these findings, Aloe vera gel extract can overcome the damaging effects of BPA on the reproductive system of rats and protects rats’ ovary folliculogenesis and hormone production against BPA-induced toxicity

کلیدواژه ها:

Aloe vera ، Bisphenol A ، Rat ، Ovary