Synthesis of PEGylated iron oxide nanoparticles as drug delivery carrier

Targeted and efficient delivery of therapeutics to tumor cells is one of the key issues in cancer therapy. In the presentwork, we report a core–shell nanoparticles comprising polymer shell coated on magnetic nanoparticles as an anticancerdrug carrier. Magnetite nanoparticles (MNPs), prepared by simple co-precipitation method, was coated withpolyethylene glycol (PEG). X-ray diffraction (XRD) was used for study of the crystalline structure of Fe3O4nanoparticles. . Size of Fe3O4 and Fe3O4@PEG core–shell nanoparticles was investigated by Dynamic light scattering(DLS) that demonstrated diameter of about 38 and 225 nm, respectively. Fourier transform infrared spectra (FTIR)provided the sufficient evidence for the presence of PEG in the Fe3O4@PEG core–shell nanoparticles. Thesenanoparticles was used as a carrier for Doxorubicin (DOX).it could be efficiently loaded in Fe3O4@PEG nanoparticles.

کلیدواژه ها:

Magnetic nanoparticles ، Drug delivery ، Doxorubicin ، Polyethylene glycol