Association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence

  • سال انتشار: 1396
  • محل انتشار: سیزدهمین کنگره بین المللی سرطان پستان
  • کد COI اختصاصی: ICBCMED13_130
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 654
دانلود فایل این مقاله

نویسندگان

Sareh Rahimi

Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.

Leila Kohan

Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.

Mohammad Mohammadianpanah

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Majid Akrami

Breast Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

چکیده

Introduction: Breast cancer is the most common form of cancer in women. Several studies in recent years reported that mutations and Single nucleotide polymorphisms (SNPs) in miRNAs are associated with the risk of various cancers. Methods: This study was performed on 267 breast cancer patients, 156 patients without recurrence of breast cancer and 111 patients with relapsing disease. After DNA extraction, genotyping was done using Tetra ARMS PCR technique. Statistical analysis of data was done using logistic regression model.Results: The results were shown that there was no significant association between mir-146a rs2910164 polymorphism with the breast cancer recurrence.Conclusions: The present study is a first study to investigate association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence. Based on the results of this study, it seems that the microRNA-146a rs2910164 polymorphism does not interfere with the pathogenesis of breast cancer recurrence.

کلیدواژه ها

Breast cancer recurrence, mir-146a, polymorphism, micro RNA

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.