Association between MTHFR C677T polymorphism and breast cancer risk in Kermanshah
- سال انتشار: 1394
- محل انتشار: دوازدهمین کنگره بین المللی سرطان پستان
- کد COI اختصاصی: ICBCMED12_149
- زبان مقاله: انگلیسی
- تعداد مشاهده: 529
نویسندگان
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah,Iran
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah,Iran
چکیده
Introduction & Aim: Breast cancer is the most common cancer in women worldwide. In Iran the average of diagnosis is about 10 years younger compared with developed countries. The genetic polymorphism in one-carbon metabolism plays an important role in breast cancer risk. We conducted a case-control study to investigate the association between MTHFR C677T polymorphism and breast cancer risk in Kermanshah population. Material and Methods: A matched case-control study was conducted using 100 newly diagnosed breast cancer patients and 197 healthy individuals as controls. Genotyping of MTHFR C677T was performed using PCR-RFLP method. Results: The frequency of MTHFR 677TT genotype in patients (10%) was significantly higher than that in controls (3%, p=0.008) that was associated with 1.97-fold (95%CI 1.16-3.36, p=0.012) increased the risk of breast cancer. Also, a significantly higher frequency of MTHFR 677T allele in patients than controls increased the susceptibility to breast cancer by 1.56 times (95%CI-1.06-2.92, p=0.024). Conclusion: Our study indicated a significant association between MTHFR C677T polymorphism and the risk of breast cancer in Kermanshah population. It is suggested that variants of one-carbon metabolism genes such as MTHFR plays a crucial role in susceptibility to breast cancerکلیدواژه ها
Breast cancer, MTHFR C677T, Polymorphism, Kermanshahمقالات مرتبط جدید
- بازتاب دانش سنتی و باورهای عامیانه مربوط به محیط زیست در مثل ها و زبانزدهای بختیاری
- سرطان چگونه به وجود می آید؟
- آشنایی با انواع سرطان و علائم آنها، راه های تشخیص و درمان
- Deciphering the Impact of the L۸۵۸R Mutation in EGFR: Computational Insights and Therapeutic Implications in Non-Small-Cell Lung Cancer
- systematic review on Investigating the relationship between obesity and breast cancer in women
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.