Spontaneous remission in a child with new onset NS . following ARF

Introduction : Either transient or permanent remission in NS is a well-known event. There are very old reports of spontaneous remission with measles and also a case of steroid resistant NS with Varicella infection. We report a case of nephrotic syndrome who developed acute renal failure(ARF) during his initial presentation and when his renal function recovered he was in remission.Spontaneous remission of NS with ARF has not been described in the written literature so far.A 6.5-year-old boy presented with acute onset of generalized edema, hypo-albuminemia(Alb.2.1mg/dl), Hypercholesterolemia(Cho.345mg/dl), ESR 61mm/hr,BUN 28,Cr 0.6mg/dl, urine protein/Cr ratio 8.Meanwhile he developed gastroenteritis and dehydration.One week following his initial presentation, he was referred to our center with severe oliguria and his lab data was as follow:BUN95mg/dl,Cr7.1mg/dl Na andK134 and 6.4 respectively.Four sessions of alternateday Hemodialysis (HD) was performed. His urine out-put showed a gradual increase and his renal function recovered completely within 2 weeks. The strikingfeature in this particular case was the remission of nephrotic syndrome with the recovery of renal function. After about 21 months he is still in remission.Conclusion: Permanent remission of nephrotic syndrome following acute renal failure is described for the first time in the literature

کلیدواژه ها:

Nephrotic syndrome ، spontaneous remission ، acute renal failure ، permanent