Which factors can be considered as predictors of sperm retrieval in non-obstructive azoospermia

Background: One of the main concerns in patients with non-obstructive azoospermia (NOA) is the lack of ejaculated spermatozoa and subsequently, the ability to predict the successful recovery of sperm fallowing testicular sperm extraction (TESE) in these patients. Therefore, the study aimed to determine the effect of some factors including the testicular hormone levels, histopathological pattern, the surgical procedure of TESE and chromosomal abnormality in predicting of the TESE outcome (sperm retrieval) and managing of the NOA patients.Methods: Testis histopathology specimen was classified to hypo-spermatogenesis; maturation arrest (MA); and Sertoli cell-only syndrome (SCOS). In the hormonal assay serum FSH, LH, testosterone and prolactin level were measured. Methods of the TESE, Micro-TESE and Karyotyping were performed according to standard methods.Result: Our finding displayed that the mean of sperm retrieval in these patients was 48.8%. The rate of sperm retrieval was significantly higher in hypospermatogenesis group compared to others (PConclusion: Accordingly, these valuable factors appear to be useful for the counseling of couples regarding the possibility of successful sperm retrieval after invasive surgery of TESE and the decision to perform oocyte pick up in his wife. However, this should not be ignored that hoping to achieve even one sperm maybe lead to perform TESE in these patients regardless of any predictive factor.

کلیدواژه ها:

Azoospermia ، Testicular histopathology ، sperm retrieval