Vitamin E reduces Polyvinyl Chloride spermatotoxic effects in Rats
محل انتشار: سومین کنگره بینالمللی تولیدمثل
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 341
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شناسه ملی سند علمی:
ISERB03_305
تاریخ نمایه سازی: 11 خرداد 1397
چکیده مقاله:
Background: It has been reported that polyvinyl chloride (PVC) is a potential reprotoxic agent. Vitamin E as a potent antioxidant can improve fertility outcomes. The goal of current study was to examine the possible protective effects of vitamin E against PVC-induced spermatotoxicities in rats.Methods: In this experimental study, 24 male Wistar rats were randomly categorized into four groups (n=6); control, vitamin E (150 mg/kg/day), PVC (1000 mg/kg/day) and vitamin E + PVC. Epididymal sperm characteristics were evaluated after 40 days.Result: Polyvinyl chloride-exposed rats exhibited significant reductions in sperm count, motility and viability compared to controls. Vitamin E co-administration attenuated PVC-induced epididymal sperm impairment.Conclusion: This study demonstrated that PVC has a considerable spermatotoxic effects in rats. However, vitamin E could exert protective activities against PVC-induced reproductive toxicities through oxidative stress inhibition.
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نویسندگان
Abbas Sadeghi
Department of Biology, Faculty of Basic Science, Urmia University, Urmia, Iran
Farah Farokhi
Department of Biology, Faculty of Basic Science, Urmia University, Urmia, Iran
Gholamreza Najafi
Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Ali Shalizar Jalali
Department of Comparative Histology & Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran