The effect of exenatide, a glucagon - like peptide-1, on adiponectin in rats with polycystic ovarian syndrome

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction. The level of adiponectin is low in women with PCOs that has been attributed to obesity which is common among these patients. The aim of this study was to investigate the effects of exenatide on the adiponectin receptors in PCO rats.Methods: Twenty eight normal cyclicity female wistar rats weighting 175-200 g were used in this study. PCOS were induced through the injection of 4 mg estradiol valerate per rat. PCO rats were treated by the different doses of exenatide (50, 100 mg/kg). The adiponectin receptors expression were evaluated using Real Time RT-PCR method.Result: The result of study showed that exenatide at different doses increased the level of adiponectin and also increased the adiponectin receptors expression that these receptors have glucose-lowering as well as anti-inflammatory effects.Conclusion: Exenatide, a glucagon-like peptide, had useful effects on diabetes mellitus and metabolic syndrome with increased adiponectin receptors expression.in PCO rats. we conclude that exenatide can improve metabolic indices and type 2 diabete in PCO rats.

کلیدواژه ها:

Adiponectin ، Diabetes mellitus ، Exenatide ، Metabolic syndrome ، Polycystic ovarian syndrome