Serum magnesium levels in polycystic ovary syndrome (PCOS) patients with insulin resistance

Background: PCOS is an endocrine-metabolic disorder affecting about 7-10% women of reproductive age worldwide. Insulin resistance (IR) has been found in up to 70% of PCOS women. Magnesium deficiency is associated with the presence of diabetes mellitus type 2 and other components of the metabolic syndrome. This study primarily focused on the investigation of serum magnesium levels as well as its relation with insulin resistance in PCOS patients.Methods: In this case control study -approved by the Ethical Committee of Babol University of Medical Science- 60 cases with PCOS attending the Fatemeh Zahra Infertility and Reproductive Center, Babol, Iran along with 90 healthy age- and body mass index (BMI)- matched controls were included. PCOS group were further divided into two subgroups (IR: n=36; NIR: n=24). Serum Magnesium levels, FBS and fasting insulin were measured in both groups. Insulin resistance was assessed using Quantitative Insulin Sensitivity Check Index (QUICKI) and Homeostasis Model Assessment (HOMA-IR) indexes. Statistical analyses were done using SPSS version 16.Result: There was not statistically significant differences between magnesium levels in two groups. In PCOS-IR, Magnesium levels were inverselycorrelated with HOMA-IR (r=-0.449, p=0.006) and FBS (r=-0.509, p=0.002) and directly correlated with QUICKI (r=0.480, p=0.003).Conclusion: The findings confirm the association between serum magnesium levels and insulin resistance.

کلیدواژه ها:

HOMA-IR ، Insulin resistance ، Magnesium ، QUICKI ، PCOS