Hydro-alcoholic extract of زrataegus aronia improves uterine histophatological changes of hypercholesterolemic rats

Background: Hypercholesterolemia is the presence of high levels of cholesterol in the blood. The diet-induced hypercholesterolemia (DIH) has detrimental effects including plasma lipid profile abnormality, non-alcoholic fatty liver disease and vascular dysfunction. Crataegus aronia has been demonstrated to have hypocholesterolemic effects and was traditionally used to treat cardiovascular diseases. The purpose of present study was to evaluate the effects of hydro-alcoholic extract of Crataegus aronia (HECA) on uterus in hypercholesterolemic rats.Methods: In this study, female Wistar rats were randomly divided into 4 equal groups including: control, HECA (200 mg/kg/day), DIH and DIH + HECA groups. Uterine histology was examined in all experimental groups after 30 days. Reductions in the number of endometrial glands and thickness of endometrium as well as endometrial glands destruction were observed in DIH group, while in DIH + HECA group above-mentioned alterations were significantly improved compared to DIH group.Result: Reductions in the number of endometrial glands and thickness of endometrium as well as endometrial glands destruction were observed in DIH group, while in DIH + HECA group above-mentioned alterations were significantly improved compared to DIH group.Conclusion: Our findings revealed that HECA can protect uterus against hypercholesterolemia associated degenerative changes in rats.

کلیدواژه ها:

Histology ، Hypercholesterolemia ، Rat ، Uterus ، Crataegus aronia